O2 etank at 3 lpm how long will it last
As this endpoint is very different from the one used by Kudrow and Fogan, these studies are difficult to compare. In this study the primary endpoint was to render the patient painfree or have adequate relief while treating a single attack. The CH attacks stopped, or adequate relief was obtained, within 15 min of oxygen usage in 78%, compared to 20% using room air. The usual oxygen flow rate applied has remained 7 L/min until the study by Cohen (2009) ( N = 76) showed that treatment with oxygen at a flow rate of 12 L/min was effective as well. The average relief score for all oxygen-treated patients was 1.93, compared to 0.77 for room air. The endpoint was a mean relief score (0 = no relief to 3 = complete relief). In a small study by Fogan (1985) ( N = 19) oxygen at a flow rate of 6 L/min was shown to be more effective than room air. In a second study by Kudrow ( N = 50), oxygen at 7 L/min was effective in 82%, compared to 70% with ergotamine. A study by Kudrow (1981) ( N = 52) demonstrated that 75% of patients treated with oxygen at a flow rate of 7 L/min have adequate or complete relief, in at least 7 out of 10 attacks.
O2 etank at 3 lpm how long will it last trial#
Dutch Trial Register ( NTR3801), registered 14 January 2013.Ĭluster headache (CH) attacks can, in many patients, be successfully treated with oxygen via a non-rebreather mask. Trial registrationĮuropean Union Clinical Trials Register ( 2012–003648-59), registered 1 October 2012.
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It might be more cost-effective, however, to start with 7 L/min and, if ineffective, to switch to 12 L/min. As most patients prefer 12 L/min and treatments were equally safe, this could be used in all patients. More patients were painfree using 7 L/min, but our other outcome measures did not confirm a difference in effect between flow rates. There is lack of evidence to support differences in the effect of oxygen at a flow rate of 12 L/min compared to 7 L/min. Also slightly more patients noticed, no or not much, relief on 7 L/min, and found 12 L/min to be effective in all their attacks. The average drop in score on this 5-point scale, however, was equal between groups. The exploratory analysis showed an odds ratio of being painfree using 12 L/min of 0.73 (95% CI 0.52–1.02) compared to 7 L/min ( p = 0.061) as scored on a 5-point scale. There were no differences in side effects or in our other secondary outcome measures. Contradicting this result, more patients were painfree using 7 L/min ( p = 0.039). Patients tended to prefer 12 L/min ( p = 0.005). We could only include 5 patients, treating 27 attacks on the first two days of the study, for our primary outcome, which did not show a significant difference ( p = 0.180). An exploratory analysis was conducted using all eligible attacks of 70 patients who provided valid data. These 56 patients recorded 604 attacks, eligible for the primary analysis. Ninety-eight patients were enrolled, 70 provided valid data, 56 used both flow rates. Secondary outcome measures were percentage of successfully treated attacks, percentage of attacks after which patients were painfree, drop in VAS score and patient preference in all treatment periods (14 days). The primary outcome measure was the percentage of attacks after which patients (treating at least 2 attacks/day) were painfree after 15 min, in the first two days of the study. In a double-blind, randomized, crossover study, oxygen naïve cluster headache patients, treated attacks with oxygen at 7 and 12 L/min. The aim of this study was to compare the effect of 100% oxygen at different flow rates for the treatment of cluster headache attacks. In previous studies oxygen at flow rates of both 7 L/min and 12 L/min was shown to be effective. Cluster headache attacks can, in many patients, be successfully treated with oxygen via a non-rebreather mask.